To NMD or not to NMD: nonsense-mediated mRNA decay in cancer and other genetic diseases
The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs
bearing premature termination codons (PTCs). Decades of work have elucidated the …
bearing premature termination codons (PTCs). Decades of work have elucidated the …
Translation‐coupled mRNA quality control mechanisms
L Monaghan, D Longman, JF Cáceres - The EMBO Journal, 2023 - embopress.org
Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Premature termination codons (PTCs) can result in the production of truncated proteins or
the degradation of messenger RNAs by nonsense-mediated mRNA decay (NMD). Which of …
the degradation of messenger RNAs by nonsense-mediated mRNA decay (NMD). Which of …
[HTML][HTML] Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
The broader sense of nonsense
ED Karousis, O Mühlemann - Trends in biochemical sciences, 2022 - cell.com
The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …
translation-dependent degradation of mRNAs harboring premature termination codons …
Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells
TD Larionova, S Bastola, TE Aksinina, KS Anufrieva… - Nature cell …, 2022 - nature.com
Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity.
However, the molecular mechanisms underlying the origin of different GBM cell populations …
However, the molecular mechanisms underlying the origin of different GBM cell populations …
[HTML][HTML] SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
V Boehm, S Kueckelmann, JV Gerbracht… - Nature …, 2021 - nature.com
Eukaryotic gene expression is constantly controlled by the translation-coupled nonsense-
mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD …
mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD …
A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes
JD Eaton, L Francis, L Davidson… - Genes & …, 2020 - genesdev.cshlp.org
The allosteric and torpedo models have been used for 30 yr to explain how transcription
terminates on protein-coding genes. The former invokes termination via conformational …
terminates on protein-coding genes. The former invokes termination via conformational …
[HTML][HTML] Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay
CM Embree, R Abu-Alhasan, G Singh - Journal of Biological Chemistry, 2022 - ASBMB
Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …
Termination of transcription by RNA polymerase II: BOOM!
JD Eaton, S West - Trends in Genetics, 2020 - cell.com
RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …
reaction always brought to a close by its termination. Because Pol II transcribes multiple …