The nonsense-mediated mRNA decay (NMD) pathway degrades some but not all mRNAs
bearing premature termination codons (PTCs). Decades of work have elucidated the …

Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

Premature termination codons (PTCs) can result in the production of truncated proteins or
the degradation of messenger RNAs by nonsense-mediated mRNA decay (NMD). Which of …

RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …

The term 'nonsense-mediated mRNA decay'(NMD) was initially coined to describe the
translation-dependent degradation of mRNAs harboring premature termination codons …

Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity.
However, the molecular mechanisms underlying the origin of different GBM cell populations …

Eukaryotic gene expression is constantly controlled by the translation-coupled nonsense-
mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD …

The allosteric and torpedo models have been used for 30 yr to explain how transcription
terminates on protein-coding genes. The former invokes termination via conformational …

Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …

RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …