A new approach for anthelmintic discovery for humans
Natural product-based drug discovery has been deemphasized by the pharmaceutical
industry. This situation is discordant with the fact that most people in developing countries …
industry. This situation is discordant with the fact that most people in developing countries …
Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents
C Tacon, EM Guantai, PJ Smith, K Chibale - Bioorganic & medicinal …, 2012 - Elsevier
Herein we report on the semisynthesis and biological evaluation of β-amino alcohol
derivatives of the natural product totarol and other simple aromatic systems. All β-amino …
derivatives of the natural product totarol and other simple aromatic systems. All β-amino …
South African abietane diterpenoids and their analogs as potential antimalarials: novel insights from hybrid computational approaches
The hemoglobin degradation process in Plasmodium parasites is vital for nutrient
acquisition required for their growth and proliferation. In P. falciparum, falcipains (FP-2 and …
acquisition required for their growth and proliferation. In P. falciparum, falcipains (FP-2 and …
Natural product-based drug discovery in Africa: The need for integration into modern drug discovery paradigms
EM Guantai, K Chibale - Drug Discovery in Africa: Impacts of Genomics …, 2012 - Springer
A myriad of infectious diseases continue to cause the death and suffering of millions of
people in sub-Saharan Africa. Efforts to mitigate this suffering involve, among others …
people in sub-Saharan Africa. Efforts to mitigate this suffering involve, among others …
Application of in silico, in vitro and in vivo ADMET/PK platforms in drug discovery
C Masimirembwa, R Thelingwani - Drug Discovery in Africa: Impacts of …, 2012 - Springer
Drug discovery is a risky and expensive business fraught with high attrition rates. The health-
care benefits and financial rewards that can be realised if successful have, however …
care benefits and financial rewards that can be realised if successful have, however …
Searching for drugs that target multiple receptors for anthelmintics from African natural products
TG Geary, E Ubalijoro - Drug Discovery in Africa: impacts of genomics …, 2012 - Springer
Assay strategies that permit mechanism-based screening for new antiparasitic drugs on-site
have been established at the Universities of Botswana and Cape Town. Researchers at …
have been established at the Universities of Botswana and Cape Town. Researchers at …