Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

Atherosclerotic vascular disease (ASVD) is the leading cause of death worldwide.
Hyperuricemia is the fourth risk factor for atherosclerosis after hypertension, diabetes, and …

Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …

Prehypertension frequently progresses to hypertension, a condition associated with high
morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors …

Asymptomatic hyperuricaemia affects~ 20% of the general population in the USA, with
variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered …

Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans.
In the process of purine metabolism, reactive oxygen species, including superoxide, are …

Hyperuricaemia is common among patients with chronic kidney disease (CKD), and
increases in severity with the deterioration of kidney function. Although existing guidelines …

Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney
disease (CKD), respectively. Despite the common association, the role of uric acid in the …

The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …