The mitotic spindle uses microtubule-based motor proteins to assemble itself and to
segregate sister chromatids. It is becoming clear that motors invoke several distinct …

Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

We have isolated a human homolog of Xenopus Eg5, a kinesin-related motor protein
implicated in the assembly and dynamics of the mitotic spindle. We report that microinjection …

Monastrol, a cell-permeable small molecule inhibitor of the mitotic kinesin, Eg5, arrests cells
in mitosis with monoastral spindles. Here, we use monastrol to probe mitotic mechanisms …

Intracellular microtubule motor proteins may direct the motile properties and/or
morphogenesis of the mitotic spindle (reviewed in ref. 3). The recent identification of kinesin …

Fluorescence in situ hybridization (FISH) shows that fission yeast centromeres and
telomeres make up specific spatial arrangements in the nucleus. Their positioning and …

The widespread reorganization of cellular architecture in mitosis is achieved through
extensive protein phosphorylation, driven by the coordinated activation of a mitotic kinase …

The functions of the Cdc28 protein kinase in DNA replication and mitosis in Saccharomyces
cerevisiae are thought to be determined by the type of cyclin subunit with which it is …

CHROMOSOME segregation during mitosis depends on the action of the mitotic spindle, a
self-organizing, bipolar protein machine which uses microtubules (MTs) and their associated …