Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Lysosomes are degradation centers and signaling hubs in cells and play important roles in
cellular homeostasis, development, and aging. Changes in lysosome function are essential …

Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …

Eukaryotes use autophagy as a mechanism for maintaining cellular homeostasis by
degrading and recycling organelles and proteins. This process assists in the proliferation …

For a long time, lysosomes were considered merely to be cellular'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …

Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic
enzymes. The detrimental consequences of lysosomal leakage have been well known since …