Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
Current advances in the elimination of hepatitis B in China by 2030
With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leading
public health challenges in China. Over the last two decades, China has made great …
public health challenges in China. Over the last two decades, China has made great …
HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA
polymerase into nucleocapsids for reverse transcriptional DNA replication to take place …
polymerase into nucleocapsids for reverse transcriptional DNA replication to take place …
[HTML][HTML] Role of Hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation
Hepatitis B virus (HBV) delivers a partially double-stranded, relaxed circular (RC) DNA
genome in complete virions to the host cell nucleus for conversion to the covalently closed …
genome in complete virions to the host cell nucleus for conversion to the covalently closed …
Current progress in the development of hepatitis B virus capsid assembly modulators: chemical structure, mode-of-action and efficacy
H Kim, C Ko, JY Lee, M Kim - Molecules, 2021 - mdpi.com
Hepatitis B virus (HBV) is a major causative agent of human hepatitis. Its viral genome
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
comprises partially double-stranded DNA, which is complexed with viral polymerase within …
The regulation of HBV transcription and replication
CE Oropeza, G Tarnow, A Sridhar, TY Taha… - Hepatitis B Virus …, 2020 - Springer
Hepatitis B virus (HBV) is a major human pathogen lacking a reliable curative therapy.
Current therapeutics target the viral reverse transcriptase/DNA polymerase to inhibit viral …
Current therapeutics target the viral reverse transcriptase/DNA polymerase to inhibit viral …
Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation
Hepatitis B virus (HBV) core protein consists of an N-terminal assembly domain and a C-
terminal domain (CTD) with seven conserved serines or threonines that are dynamically …
terminal domain (CTD) with seven conserved serines or threonines that are dynamically …
Recent advances in the development of HBV capsid assembly modulators
B Nijampatnam, DC Liotta - Current opinion in chemical biology, 2019 - Elsevier
Hepatitis B virus (HBV) infections represent a significant burden on global public health.
Current HBV treatments using nucleos (t) ide analogs (NAs) and PEG interferons cannot …
Current HBV treatments using nucleos (t) ide analogs (NAs) and PEG interferons cannot …
Protein phosphatase 1 catalyzes HBV core protein dephosphorylation and is co-packaged with viral pregenomic RNA into nucleocapsids
Hepatitis B virus (HBV) replicates its genomic DNA via viral DNA polymerase self-primed
reverse transcription of a RNA pre-genome in the nucleocapsid assembled by 120 core …
reverse transcription of a RNA pre-genome in the nucleocapsid assembled by 120 core …
Amino acid residues at core protein dimer-dimer interface modulate multiple steps of hepatitis B virus replication and HBeAg biogenesis
The core protein (Cp) of hepatitis B virus (HBV) assembles pregenomic RNA (pgRNA) and
viral DNA polymerase to form nucleocapsids where the reverse transcriptional viral DNA …
viral DNA polymerase to form nucleocapsids where the reverse transcriptional viral DNA …