Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

The neural crest is a multipotent, migratory cell population that is unique to vertebrate
embryos and gives rise to many derivatives, ranging from the peripheral nervous system to …

Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate
restriction to specific fates occurs. The direct fate restriction model hypothesises that …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

Rates of cell proliferation in the vertebrate intestinal epithelium are modulated by intrinsic
signaling pathways and extrinsic cues. Here, we report that epithelial cell proliferation in the …

The role of Anti-Müllerian hormone (Amh) during gonad development has been studied
extensively in mammals, but is less well understood in other vertebrates. In male …

The neural crest is a multipotent stem cell–like population that gives rise to a wide range of
derivatives in the vertebrate embryo including elements of the craniofacial skeleton and …

sox10 is necessary for development of neural and pigment cell derivatives of the neural
crest (NC). However, whereas a direct role for Sox10 activity has been established in …

For both vertebrate developmental and evolutionary biologists, and also for clinicians, the
neural crest (NC) is a fundamental cell population. An understanding of Sox10 function in …

The auditory organ of Corti is comprised of only two major cell types—the mechanosensory
hair cells and their associated supporting cells—both specified from a single pool of …