Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …

Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell
contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is …

Neuroprotectant strategies that have worked in rodent models of stroke have failed to
provide protection in clinical trials. Here we show that the opposite circadian cycles in …

Multiple viral pathogens can pose a significant health risk to individuals. As a recent
example, the β-coronavirus family virion, SARS-CoV-2, has quickly evolved as a pandemic …

A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral …

Background: The mammalian circadian clock and its associated clock genes are
increasingly been recognized as critical components for a number of physiological and …

An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …

The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which
regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of …

Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …

The global increase in lifespan noted not only in developed nations, but also in large
developing countries parallels an observed increase in a significant number of non …