Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …

Lung cancer has a poor prognosis; over half of people diagnosed with lung cancer die
within one year of diagnosis and the 5-year survival is less than 18%. Non-small cell lung …

Lung cancer remains the leading cause of cancer mortality in men and women in the US
and worldwide. About 90% of lung cancer cases are caused by smoking and the use of …

The epithelial-to-mesenchymal transition (EMT) is a cell biological program that confers
mesenchymal traits on carcinoma cells and drives their metastatic dissemination. It is …

The TGF-β signaling pathway governs key cellular processes under physiologic conditions
and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional …

Transforming growth factor-β (TGFβ) is an immunosuppressive cytokine produced by tumour
cells and immune cells that can polarize many components of the immune system. This …

Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that has profound
regulatory effects on many developmental and physiological processes. Disruption of the …

Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …

▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …