Abstract Corona virus disease 2019 (COVID‐19) causes symptoms from multiple organs
after infection by severe acute respiratory syndrome corona virus 2 (SARS CoV‐2). They …

Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …

INTRODUCTION In Alzheimer's disease (AD), the production of amyloid β (Aβ) oligomers
and downstream tau dysfunction are thought to cause neuronal damage, in particular a loss …

The incidence of stroke and dementia are diverging across the world, rising for those in low-
and middle-income countries and falling in those in high-income countries. This suggests …

To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal
activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and …

Age-related phenotypic changes of cerebromicrovascular endothelial cells lead to
dysregulation of cerebral blood flow and blood-brain barrier disruption, promoting the …

Early in Alzheimer's disease (AD), pericytes constrict capillaries, increasing their hydraulic
resistance and trapping of immune cells and, thus, decreasing cerebral blood flow (CBF) …

The blood–brain barrier (BBB) regulates the delivery of oxygen and important nutrients to
the brain through active and passive transport and prevents neurotoxins from entering the …

Gut microbiota in interaction with intestinal host tissues influences many brain functions and
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …