Microfluidic devices enable novel means of emulating neurodegenerative disease
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …

Three-dimensional hydrogel-based organ-like cultures can be applied to study
development, regeneration, and disease in vitro. However, the control of engineered …

Neuronal models are a crucial tool in neuroscientific research, helping to elucidate the
molecular and cellular processes involved in disorders of the nervous system. Adapting …

Axons are a unique cellular structure that allows for the communication between neurons.
Axon damage compromises neuronal communications and often leads to functional deficits …

Neurodegenerative disorders (ND) are characterized by the progressive and irreversible
loss of neurons. Alzheimer's Disease (AD) is the most incident age-related ND, in which the …

Multidomain peptide (MDP) hydrogels are a class of self-assembling materials that have
been shown to elicit beneficial responses for soft tissue regeneration. However, their …

The mammalian target of rapamycin (mTOR) positively regulates axon growth in the
mammalian central nervous system (CNS). Although axon regeneration and functional …

Peripheral nerve injury is one of common traumas. Although injured peripheral nerves have
the capacity to regenerate, axon regeneration proceeds slowly and functional outcomes are …

Development of technology platforms to perform compound screens of human induced
pluripotent stem cell (hiPSC)-derived neurons with relatively high throughput is essential to …

We report a method to generate a 3D motor neuron model with segregated and directed
axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a …