LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases
and the only two members of the LIM kinase family. They play a crucial role in the regulation …

All eukaryotic cells are composed of the cytoskeleton, which plays crucial roles in
coordinating diverse cellular functions such as cell division, morphology, migration …

Abstract α-Synuclein (α-Syn) is closely related to the pathogenesis of Parkinson's disease
(PD). Under pathological conditions, the conformation of α-syn changes and different forms …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and …

This comprehensive review explores the complex role of cofilin, an actin-binding protein,
across various neurodegenerative diseases (Alzheimer's, Parkinson's, schizophrenia …

The pathological hallmark of Parkinson's disease (PD) is the presence of Lewy bodies (LBs)
with aggregated α-synuclein being the major component. The abnormal α-synuclein …

Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD).
Specifically, alpha-synuclein (αSyn) accumulation in the hippocampus leading to synaptic …

Oxidative stress on cysteine (Cys)-containing proteins has been associated with
physiological disorders, as suggested for the human cofilin-1 (CFL-1) protein, in which the …

Taxol is commonly used chemotherapy regimen for esophageal squamous cell carcinoma
(ESCC). Study of the underlying mechanisms of Taxol chemoresistance provides better …

Parkinson's disease (PD) is characterized by the accumulation of misfolded α-synuclein
protein and the loss of dopaminergic neurons in the substantia nigra. Abnormal α-synuclein …