ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …

Oligomeric intermediates are non-fibrillar polypeptide assemblies that occur during amyloid
fibril formation and that are thought to underlie the aetiology of amyloid diseases, such as …

The receptor for advanced glycation end products (RAGE) is a central signaling molecule in
the innate immune system and is involved in the onset and sustainment of the inflammatory …

Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …

Thioflavin-T (ThT) is one of the most commonly used dyes for amyloid detection, but the
origin of its fluorescence enhancement is not fully understood. Herein we have …

Inflammation plays an important role in Alzheimer's disease (AD) and other
neurodegenerative disorders. Although chronic inflammation in later stages of AD is well …

The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved
in inflammatory disorders, tumor outgrowth, diabetic complications and Alzheimer's disease …

The monoclonal antibody 2A4 binds an epitope derived from a cleavage site of serum
amyloid protein A (sAA) containing a-Glu-Asp-amino acid pairing. In addition to its reactivity …

There are at least 20 distinct types of systemic amyloidosis, all of which result in the organ-
compromising accumulation of extracellular amyloid deposits. Amyloidosis is challenging to …

Oligomers are intermediates of the β-amyloid (Aβ) peptide fibrillogenic pathway and are
putative pathogenic culprits in Alzheimer's disease (AD). Here we report the …