Controlled assembly and disassembly of multi-protein complexes is central to cellular
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …

Here, we survey the diverse functions of DNA polymerase ζ (pol ζ) in eukaryotes. In
mammalian cells, REV3L (3130 residues) is the largest catalytic subunit of the DNA …

DNA double-strand breaks (DSBs) are repaired through homology-directed repair (HDR) or
non-homologous end joining (NHEJ). BRCA1/2-deficient cancer cells cannot perform HDR …

To exploit vulnerabilities of tumors, it is urgent to identify associated defects in genome
maintenance. One unsolved problem is the mechanism of regulation of DNA double‐strand …

A critical determinant of DNA repair pathway choice is REV7, an adaptor that binds to
various DNA repair proteins through its C-terminal seatbelt domain. The REV7 seatbelt …

Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least
one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and …

Abstract MAD2L2 (REV7) plays an important role in DNA double-strand break repair. As a
member of the shieldin complex, consisting of MAD2L2, SHLD1, SHLD2 and SHLD3, it …

The HORMA domain protein REV7, also known as MAD2L2, interacts with a variety of
proteins and thereby contributes to the establishment of different complexes. With doing so …

Abstract Shieldin, including SHLD1, SHLD2, SHLD3 and REV7, functions as a bridge linking
53BP1-RIF1 and single-strand DNA to suppress the DNA termini nucleolytic resection …

During meiosis, homologous chromosomes must recognize, pair, and recombine with one
another to ensure the formation of inter-homologue crossover events, which, together with …