Sleep deprivation is highly prevalent in the modern world, possibly reaching epidemic
proportions. While multiple theories regarding the roles of sleep exist (inactivity, energy …

Sleep comprises approximately one-third of a person's lifetime, but its impact on health and
medical conditions remains partially unrecognized. The prevalence of sleep disorders is …

The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of
β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep …

Acute sleep deprivation (ASD) is often observed in shift workers and characterized by
drowsiness and unrelenting exhaustion. The physiological and psychological effects of ASD …

Most animals require sleep, and sleep loss induces serious pathophysiological
consequences, including death. Previous experimental approaches for investigating sleep …

Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to
cognitive impairment, psychological symptoms, and neurodegeneration. This study aimed to …

Dopamine D2 receptors are involved with wakefulness, but their role in the decreased
alertness associated with sleep deprivation is unclear. We had shown that sleep deprivation …

Aims Given the lasting impact of chronic paradoxical sleep deprivation (PSD) on behavior
and organism metabolic alternations, along with the role of the microbiome in …

Although epidemiological studies indicate that sleep-disordered breathing (SDB) such as
obstructive sleep apnea is a strong risk factor for the development of Alzheimer's disease …

Sleep is a vital and evolutionarily conserved process, critical to daily functioning and
homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental …