Early detection and diagnosis of many cancers is very challenging. Late stage detection of a
cancer always leads to high mortality rates. It is imperative to develop novel and more …

Antibody–oligonucleotide conjugates (AOCs) are a novel class of synthetic chimeric
biomolecules that has been continually gaining traction in different fields of modern …

Among the vast number of recognition molecules, DNA aptamers generated from cell-
SELEX exhibit unique properties for identifying cell membrane biomarkers, in particular …

Membrane proteins on the cell surface perform a myriad of biological functions; however,
ligand discovery for membrane proteins is highly challenging, because a natural cellular …

Aptamer-based detection and therapy have made substantial progress with cost control and
easy modification. However, the conformation lability of an aptamer typically causes the …

Covalent aptamers are novel biochemical tools for fast and selective transfer of labels to
target proteins. Equipped with cleavable electrophiles, these nucleic acid probes enable the …

A novel electrochemical biosensor based on AuNPs/Ti 3 C 2 MXene three-dimensional
nanocomposite for sensitive miRNA-155 detection by exonuclease III (Exo III)-aided …

Conjugation of various reagents to antibodies has long been an elegant way to combine the
superior binding features of the antibody with other desired but non-natural functions …

Multivalent interactions of biomolecules play pivotal roles in physiological and pathological
settings. Whereas the directionality of the interactions is crucial, the state‐of‐the‐art …

Cell surface engineering represents one of the most vanguard fields in biomedical research.
This technology aims to artificially retrofit the surfaces of different types of cells by means of …