Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
gradual loss of memory and cognitive function, which constitutes a heavy burden on the …

The glucose-regulated proteins (GRPs) are stress-inducible chaperones that mostly reside
in the endoplasmic reticulum or the mitochondria. Recent advances show that the GRPs …

Objectives Understanding the novel coronavirus (COVID-19) mode of host cell recognition
may help to fight the disease and save lives. The spike protein of coronaviruses is the main …

Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival
advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Cancer progression is characterized by rapidly proliferating cancer cells that are in need of
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically
distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and …

The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family
chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP …

Over the past few decades, understandings and evidences concerning the role of
endoplasmic reticulum (ER) stress in deciding the cell fate have been constantly growing …