Background Understanding why people take part in health research is critical to improve
research efficiency and generalisability. The aim of this overview of systematic reviews was …

Background Recruiting participants into clinical trials continues to be a challenge, which can
result in study delay or termination. Recent studies have used social media to enhance …

Digital technologies such as smartphones are transforming the way scientists conduct
biomedical research. Several remotely conducted studies have recruited thousands of …

Background We previously found that 25% of 1,017 randomized clinical trials (RCTs)
approved between 2000 and 2003 were discontinued prematurely, and 44% remained …

Background Severe complicated intra-abdominal sepsis (SCIAS) has an increasing
incidence with mortality rates over 80% in some settings. Mortality typically results from …

Background Poor participant recruitment is the most frequent reason for premature
discontinuation of randomized clinical trials (RCTs), particularly if they are investigator …

Objective To evaluate the impact of the QuinteT Recruitment Intervention (QRI) on
recruitment in challenging randomized controlled trials (RCTs) that have applied the …

There is increasing interest in clinical trials that use technologies and other innovative
operational approaches to organise trial activities around trial participants instead of …

Aims The aim of the study was to identify actionable learning points from stakeholders in
remote decentralised clinical trials (RDCTs) to inform their future design and conduct …

Objective To describe patient perspectives on recruitment and retention in clinical trials.
Study Design and Setting Systematic review of qualitative studies that reported the …