Synaptic mechanisms underlying persistent cocaine craving
ME Wolf - Nature reviews neuroscience, 2016 - nature.com
Although it is challenging for individuals with cocaine addiction to achieve abstinence, the
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …
greatest difficulty is avoiding relapse to drug taking, which is often triggered by cues …
The link between schizophrenia and substance use disorder: A unifying hypothesis
JY Khokhar, LL Dwiel, AM Henricks, WT Doucette… - Schizophrenia …, 2018 - Elsevier
Substance use disorders occur commonly in patients with schizophrenia and dramatically
worsen their overall clinical course. While the exact mechanisms contributing to substance …
worsen their overall clinical course. While the exact mechanisms contributing to substance …
Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses
Reward drives motivated behaviours and is essential for survival, and therefore there is
strong evolutionary pressure to retain contextual information about rewarding stimuli. This …
strong evolutionary pressure to retain contextual information about rewarding stimuli. This …
[HTML][HTML] Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens
Excitatory afferents to the nucleus accumbens (NAc) are thought to facilitate reward seeking
by encoding reward-associated cues. Selective activation of different glutamatergic inputs to …
by encoding reward-associated cues. Selective activation of different glutamatergic inputs to …
[HTML][HTML] BLA to vHPC inputs modulate anxiety-related behaviors
The basolateral amygdala (BLA) and ventral hippocampus (vHPC) have both been
implicated in mediating anxiety-related behaviors, but the functional contribution of BLA …
implicated in mediating anxiety-related behaviors, but the functional contribution of BLA …
Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior
AC Felix-Ortiz, KM Tye - Journal of Neuroscience, 2014 - Soc Neuroscience
Impairments in social interaction represent a core symptom of a number of psychiatric
disease states, including autism, schizophrenia, depression, and anxiety. Although the …
disease states, including autism, schizophrenia, depression, and anxiety. Although the …
Sex differences in antidepressant efficacy
TA LeGates, MD Kvarta, SM Thompson - Neuropsychopharmacology, 2019 - nature.com
Sex differences have been observed across many psychiatric diseases, especially mood
disorders. For major depression, the most prevalent psychiatric disorder, females show a …
disorders. For major depression, the most prevalent psychiatric disorder, females show a …
[HTML][HTML] The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?
BP Godsil, JP Kiss, M Spedding, TM Jay - European …, 2013 - Elsevier
While the hippocampal formation and the prefrontal cortex each have a well-established role
in cognitive and mnemonic processes, the extent and manner in which these structures …
in cognitive and mnemonic processes, the extent and manner in which these structures …
[HTML][HTML] Cortico-basal ganglia reward network: microcircuitry
SR Sesack, AA Grace - Neuropsychopharmacology, 2010 - nature.com
Many of the brain's reward systems converge on the nucleus accumbens, a region richly
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …
innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry …
[HTML][HTML] The hippocampal-VTA loop: controlling the entry of information into long-term memory
JE Lisman, AA Grace - Neuron, 2005 - cell.com
In this article we develop the concept that the hippocampus and the midbrain dopaminergic
neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop …
neurons of the ventral tegmental area (VTA) form a functional loop. Activation of the loop …