Cofilin and actin-depolymerizing factor (ADF) are actin-binding proteins that play an
essential role in regulating actin filament dynamics and reorganization by stimulating the …

Neurons are among the most highly polarized cell types in the body, and the polarization of
axon and dendrites underlies the ability of neurons to integrate and transmit information in …

The LIM kinase family consists of just two members: LIM kinase 1 (LIMK1) and LIM kinase 2
(LIMK2). With uniquely organised signalling domains, LIM kinases are regulated by several …

The brain changes in response to experience and altered environment. This neural plasticity
is largely mediated by morphological and functional modification of synapses, a process that …

Mammalian target of rapamycin (mTOR) is a serine–threonine protein kinase that regulates
several intracellular processes in response to extracellular signals, nutrient availability …

The members of the LIM kinase (LIMK) family, which include LIMK 1 and 2, are serine
protein kinases involved in the regulation of actin polymerisation and microtubule …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …

The androgen receptor (AR) plays a critical role in prostate cancer. We have identified a
ubiquitin E3 ligase, RNF6, as an AR-associated protein in a proteomic screen. RNF6 …

LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases
and the only two members of the LIM kinase family. They play a crucial role in the regulation …

Two forms of X-chromosome inactivation (XCI) ensure the selective silencing of female sex
chromosomes during mouse embryogenesis. Imprinted XCI begins with the detection of Xist …