During development and throughout life, a variety of specialized cells must be generated to
ensure the proper function of each tissue and organ. Chromatin plays a key role in …

Gene expression programmes conferring cellular identity are achieved through the
organization of chromatin structures that either facilitate or impede transcription. Among the …

Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …

Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell
and a differentiating daughter cell. How non-genic information could be inherited …

Within the cell nucleus, the organization of the eukaryotic DNA into chromatin uses histones
as components of its building block, the nucleosome. This chromatin organization …

Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the
centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability …

Epigenetic mechanisms play essential roles in determining distinct cell fates during the
development of multicellular organisms. Histone proteins represent crucial epigenetic …

Asymmetric cell division produces two cells that are genetically identical but each have
distinctly different cell fates. During this process, epigenetic mechanisms play an important …

The discovery of biased histone inheritance in asymmetrically dividing Drosophila
melanogaster male germline stem cells demonstrates one means to produce two distinct …

Centromeres are built on repetitive DNA sequences (CenDNA) and a specific chromatin
enriched with the histone H3 variant CENP‐A, the epigenetic mark that identifies centromere …