Abstract Development of the forebrain critically depends on the Sonic Hedgehog (Shh)
signaling pathway, as illustrated in humans by the frequent perturbation of this pathway in …

Ciliary transport in eukaryotic cells is an intricate and conserved process involving the
coordinated assembly and functioning of a multiprotein intraflagellar transport (IFT) complex …

Vision impairment places a serious burden on the aging society, affecting the lives of
millions of people. Many retinal diseases are of genetic origin, of which over 50% are due to …

Primary cilia are antenna-like organelles which sense extracellular cues and act as
signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as …

Cilia and the nucleus were two defining features of the last eukaryotic common ancestor. In
early eukaryotic evolution, these structures evolved through the diversification of a common …

Bin/Amphiphysin/Rvs (BAR) domains are highly conserved domains found in all eukaryotes.
BAR domain proteins form crescent-shaped dimers that sense and sculpt curved lipid …

Primary cilia protrude from the apical surface of many cell types and act as a sensory
organelle that regulates diverse biological processes ranging from chemo-and …

Introduction: SNPs associated with genome-wide risk for multiple sclerosis (MS) modulate
expression of ankyrin repeat domain protein 55 (ANKRD55). The function of ANKRD55 is …

Chickens are important breeding animals and models for biomedical research, particularly
due to their oviparous nature, which makes it an ideal subject for studying maternal effects …

In dieser Arbeit wurde eine HEK 293T-Zelllinie etabliert, die das NPH-Protein NPHP15
(CEP164) gekoppelt an ein Flag-Tag exprimiert. Mittels Co-Immunpräzipitation und …