There has been great attention on indoleamine-2, 3-dioxygenase 1 (IDO1) around cancer
immunotherapy because of its role in enabling cancers to evade the immune system. The …

The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …

Iron-containing enzymes such as heme enzymes play crucial roles in biological systems.
Three distinct heme-containing dioxygenase enzymes, tryptophan 2, 3-dioxygenase (TDO) …

Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophan 2, 3-dioxygenase (TDO) are
involved in the key steps of tryptophan metabolism and are potential new targets for tumor …

An electrooxidative reconstruction of the indole core under ambient conditions is reported,
resulting in the construction of tryptanthrins. This electrochemical strategy simplifies …

A variety of novel tryptanthrin aminothiazole analogues 3a‐h and 5a‐h possessing a
biologically active thiazole moiety were synthesized by the reaction of tryptanthrin …

A method for one‐pot synthesis of 6‐benzyl‐6‐hydroxyindolo [2, 1‐b] quinazolin‐12 (6H)‐
ones from isatins and potassium benzyl trifluoroborates was developed. Bioactive …

In our endeavor towards the development of potent molecules for cancer diseases, we have
designed and synthesized a series of 2, 4, 5-trisubstituted imidazole derivatives (B1–B24) …

Abstract The novel titled compound 2-[(Anthracene-9-ylmethylene) amino]-2-methylpropane-
1, 3-diol (AMD) has been synthesized by slow evaporation technique from mixed solvent …

A novel procedure for a one-pot cascade reaction of o-aminoacetophenones and
aryl/aliphatic isocyanates catalyzed/oxidized by the [Pd]/[Ag] system was developed. The …