In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Experimental observations indicate that Ca 2+-induced Ca 2+ release (CICR) may underlie
Ca 2+ oscillations in a variety of cells. In its original version, a theoretical model for signal …

Biological Screening of Plant Coumarins Page 1 Division of Pharmacognosy Department of
Pharmacy Faculty of Science University of Helsinki Biological Screening of Plant Coumarins …

Protein translocation between different subcellular compartments might play a significant
role in various signal transduction pathways. The S100 family is comprised of the …

Mammalian non-selective transient receptor potential cation channels (TRPCs) are
important in the regulation of cellular calcium homeostasis. In thyroid cells, including rat …

The aim of the present study was to investigate the regulation of calcium influx in thyroid
FRTL-5 cells. Stimulating Fura 2-loaded cells with thapsigargin rapidly increased the …

The expression of the P2 receptors and their functional responses were studied in rat thyroid
FRTL‐5 cells. RT‐PCR analysis revealed transcripts for the G protein‐coupled P2Y2, P2Y4 …

Several growth factors may stimulate proliferation of thyroid cells. This effect has, in part,
been dependent on calcium entry. In the present study using FRTL‐5 cells, we show that in …

Cotinine is the major metabolite of nicotine. It has some biological activity, but its
pathophysiological effects are largely unclear. We studied whether cotinine initiates calcium …

In PC-Cl3 rat thyroid cell line, ATP and UTP provoked a transient increase in [Ca2+] i,
followed by a lower sustained phase. Removal of extracellular Ca2+ reduced the initial …