Correlations of FRMD7 gene mutations with ocular oscillations

L Huang, Y Zhou, W Chen, P Lin, Y Xie, K He… - Scientific Reports, 2022 - nature.com
Mutations in the FERM domain containing 7 (FRMD7) gene have been proven to be
responsible for infantile nystagmus (IN). The purpose of this study is to investigate FRMD7 …

FRMD7 Gene Alterations in a Pakistani Family Associated with Congenital Idiopathic Nystagmus

MW Arshad, MI Shabbir, S Asif, M Shahzad, L Leydier… - Genes, 2023 - mdpi.com
Congenital idiopathic nystagmus (CIN) is an oculomotor disorder characterized by repetitive
and rapid involuntary movement of the eye that usually develops in the first six months after …

Truncated FRMD7 proteins in congenital Nystagmus: novel frameshift mutations and proteasomal pathway implications

Y Su, J Zhang, J Gao, G Ding, H Jiang, Y Liu, Y Li… - BMC Medical …, 2024 - Springer
Idiopathic congenital nystagmus (ICN) manifests as involuntary and periodic eye
movements. To identify the genetic defect associated with X-linked ICN, Whole Exome …

A start codon mutation of the FRMD7 gene in two Korean families with idiopathic infantile nystagmus

JH Choi, JH Shin, JH Seo, JH Jung, KD Choi - Scientific Reports, 2015 - nature.com
Idiopathic infantile nystagmus (IIN) is the involuntary oscillation of the eyes with onset in the
first few months of life. The most common form of inheritance is X-linked and mutations in …

Next‐generation sequencing identifies a novel frameshift variant in FRMD7 in a Chinese family with idiopathic infantile nystagmus

F Wang, H Guan, W Liu, G Zhao… - Journal of clinical …, 2020 - Wiley Online Library
Background Idiopathic infantile nystagmus (IIN) is a high genetically heterogeneous
ophthalmic disease and is often associated with pathogenic mutations in FRMD7 and …

A novel frameshift mutation in FRMD7 causes X-linked infantile nystagmus in a Chinese family

J Chen, Y Wei, L Tian, X Kang - BMC Medical Genetics, 2019 - Springer
Background Infantile nystagmus (IN) is an oculomotor disorder that is characterized by
conjugate involuntary, rapid and repetitive movement of the eyes. To date, the pathogenesis …

Identification and functional characterization of a novel missense mutation in FRMD7 responsible for idiopathic congenital nystagmus

Z Wang, M Wang, C Wang, B Lu - Acta biochimica et biophysica …, 2019 - academic.oup.com
Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement
disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most …

Identification of a novel idiopathic congenital nystagmus‑causing missense mutation, p. G296C, in the FRMD7 gene

Y Xiu, Y Yao, T Yang, M Pan… - Molecular …, 2018 - spandidos-publications.com
Exploring the genetic basis for idiopathic congenital nystagmus is critical for improving our
understanding of its molecular pathogenesis. In the present study, direct sequencing using …

[PDF][PDF] FRMD7 基因所致X 连锁特发性先天性眼球震颤的研究进展

YKX Bao - cdn.amegroups.cn
特发性先天性眼球震颤(idiopathic congenital nystagmus, ICN) 是一种常见的眼科疾病,
患者常有明显的特征性的眼部异常, 多伴有学习, 社交障碍, 对其身心健康影响较大. ICN …

Two novel FRMD7 frameshift mutation identified in two Chinese pedigrees with congenital nystagmus as producing truncated proteins

Y Su, J Zhang, J Gao, G Ding, H Jiang, Y Liu, Y Li… - 2023 - researchsquare.com
Idiopathic congenital nystagmus (ICN) is a condition characterized by involuntary and
periodic eye movements. To identify the genetic defect associated with X-linked ICN, we …