Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

In type 2 diabetes, chronic hyperglycemia is suggested to be detrimental to pancreatic β
cells, causing impaired insulin secretion. IL-1β is a proinflammatory cytokine acting during …

Elevated serum levels of acute-phase proteins, indicating chronic subclinical inflammation,
have been associated with cardiovascular disease as well as the insulin resistance …

Several studies suggest that inflammation plays a role in the pathogenesis of some glucose
disorders in adults. We tested this hypothesis in a longitudinal cohort study of older …

There is a progressive deterioration in β-cell function and mass in type 2 diabetics. It was
found that islet function was about 50% of normal at the time of diagnosis, and a reduction in …

Blood glucose concentrations are controlled by a loop incorporating two components, the
beta cells which secrete insulin and the insulin-sensitive tissues (liver, muscle, adipose) …

The underlying cause of type 1 diabetes, loss of β-cell function, has become the therapeutic
target for a number of interventions in patients with type 1 diabetes. Even though insulin …

Pancreatic islet β-cell death occurs in type 1 and 2 diabetes mellitus, leading to absolute or
relative insulin deficiency. β-cell death in type 1 diabetes is due predominantly to …

Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of
both Type 1 and Type 2 diabetes. This underlies the absolute or relative insulin insufficiency …