G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

G protein-gated inwardly rectifying potassium (GIRK) channels are essential regulators of
cell excitability in the brain. While they are implicated in a variety of neurological diseases in …

Opioid addiction is a chronically relapsing disorder that causes critical public health
problems. Currently, there is a lack of effective drug treatment. Herein, one cannabidiol …

The discovery of functionally biased and physiologically beneficial ligands directed toward G-
protein coupled receptors (GPCRs) has provided the impetus to design dopamine D2 …

We integrated genomic and bioinformatic analyses, using data from the largest genome-
wide association study of cocaine dependence (CD; n= 6546; 82.37% with CD; 57.39 …

Abstract Sorting Nexin 27 (SNX27) is a brain-enriched endosome-associated cargo adaptor
that shapes excitatory control, being relevant for cognitive and reward processing, and for …

G-protein-gated inwardly rectifying K+(GIRK) channels are essential effectors of inhibitory
neurotransmission in the brain. GIRK channels have been implicated in diseases with …

The renal dopaminergic system has been identified as a modulator of sodium balance and
blood pressure. According to the Centers for Disease Control and Prevention, in 2018 in the …

Neonatal abstinence syndrome (NAS) is a constellation of signs of withdrawal occurring
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …

Endocytosis is a fundamental process that controls protein/lipid composition of the plasma
membrane, thereby shaping cellular metabolism, sensing, adhesion, signaling, and nutrient …