M2b macrophage polarization and its roles in diseases

L Wang, S Zhang, H Wu, X Rong… - Journal of leukocyte …, 2019 - academic.oup.com
Macrophages play an important role in a wide variety of physiologic and pathologic
processes. Plasticity and functional polarization are hallmarks of macrophages …

Akt signaling pathway in macrophage activation and M1/M2 polarization

E Vergadi, E Ieronymaki, K Lyroni… - The Journal of …, 2017 - journals.aai.org
Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …

Macrophage polarization in chronic inflammatory diseases: killers or builders?

L Parisi, E Gini, D Baci, M Tremolati… - Journal of …, 2018 - Wiley Online Library
Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

Molecular mechanisms that influence the macrophage M1–M2 polarization balance

N Wang, H Liang, K Zen - Frontiers in immunology, 2014 - frontiersin.org
As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

XY Xiong, L Liu, QW Yang - Progress in neurobiology, 2016 - Elsevier
Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

[HTML][HTML] The M1 and M2 paradigm of macrophage activation: time for reassessment

FO Martinez, S Gordon - F1000prime reports, 2014 - ncbi.nlm.nih.gov
Macrophages are endowed with a variety of receptors for lineage-determining growth
factors, T helper (Th) cell cytokines, and B cell, host, and microbial products. In tissues …

Microglial and macrophage polarization—new prospects for brain repair

X Hu, RK Leak, Y Shi, J Suenaga, Y Gao… - Nature Reviews …, 2015 - nature.com
The traditional view of the adult brain as a static organ has changed in the past three
decades, with the emergence of evidence that it remains plastic and has some regenerative …

Macrophage polarization and allergic asthma

A Saradna, DC Do, S Kumar, QL Fu, P Gao - Translational Research, 2018 - Elsevier
Allergic asthma is associated with airway inflammation and airway hyperresponsiveness.
Macrophage polarization has been shown to have a profound impact on asthma …

MiRNA-mediated macrophage polarization and its potential role in the regulation of inflammatory response

K Essandoh, Y Li, J Huo, GC Fan - Shock, 2016 - journals.lww.com
Monocytes and macrophages are important components of the immune system, specialized
in either removing pathogens as part of innate immunity or contributing to adaptive immunity …

Bioactive glass-elicited stem cell-derived extracellular vesicles regulate M2 macrophage polarization and angiogenesis to improve tendon regeneration and functional …

H Xu, Y Zhu, AWT Hsiao, J Xu, W Tong, L Chang… - Biomaterials, 2023 - Elsevier
Effective countermeasures for tendon injury remains unsatisfactory. Mesenchymal stem cell-
derived extracellular vesicles (MSC-EVs)-based therapy via regulation of Mφ-mediated …