Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …
association analyses and candidate gene approaches illustrate the multigenic complexity of …
[HTML][HTML] ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1
Z Han, X Wang, Z Xu, Y Cao, R Gong, Y Yu, Y Yu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) RNA modification, a dynamic and reversible process,
is essential for tissue development and pathogenesis. However, the potential involvement of …
is essential for tissue development and pathogenesis. However, the potential involvement of …
miR-149-3p regulates the switch between adipogenic and osteogenic differentiation of BMSCs by targeting FTO
Bone marrow-derived mesenchymal stem cells (BMSCs) have been suggested to possess
the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell …
the capacity to differentiate into different cell lineages. Maintaining a balanced stem cell …
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury
R Gong, X Wang, H Li, S Liu, Z Jiang, Y Zhao… - Pharmacological …, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A), one of the important epigenitic modifications, is
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration
R Gong, Z Jiang, N Zagidullin, T Liu… - Signal Transduction and …, 2021 - nature.com
With the high morbidity and mortality rates, cardiovascular diseases have become one of the
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …
most concerning diseases worldwide. The heart of adult mammals can hardly regenerate …
The roles of lncRNA in myocardial infarction: molecular mechanisms, diagnosis biomarkers, and therapeutic perspectives
L Xie, Q Zhang, J Mao, J Zhang, L Li - Frontiers in cell and …, 2021 - frontiersin.org
In recent years, long non-coding RNAs (lncRNAs) have been demonstrated to be associated
with many physiological and pathological processes in cardiac. Recent studies have shown …
with many physiological and pathological processes in cardiac. Recent studies have shown …
Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration
N Abbas, F Perbellini, T Thum - Basic Research in Cardiology, 2020 - Springer
Soon after birth, the regenerative capacity of the mammalian heart is lost, cardiomyocytes
withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved …
withdraw from the cell cycle and demonstrate a minimal proliferation rate. Despite improved …
Recent advances on the roles of LncRNAs in cardiovascular disease
Y Fang, Y Xu, R Wang, L Hu, D Guo… - Journal of Cellular …, 2020 - Wiley Online Library
Cardiovascular diseases are a main cause of mortality whose prevalence continues to
increase worldwide. Long non‐coding RNAs (lncRNAs) regulate a variety of biological …
increase worldwide. Long non‐coding RNAs (lncRNAs) regulate a variety of biological …
Non-coding RNA therapeutics for cardiac regeneration
A growing body of evidence indicates that cardiac regeneration after myocardial infarction
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …