Parkinson's disease (PD) is a neurodegenerative disorder associated with the death of
dopaminergic neurons within the substantia nigra of the brain. Melanoma is a cancer of …

The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues
(blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological …

Introduction Alpha-synuclein (α-syn) aggregation is the pathological hallmark of Parkinson's
Disease (PD). In this study, we measured α-syn total (α-syn total), oligomeric α-syn (α-syn …

Abnormal accumulation of microtubule-associated protein tau (τ) is a characteristic feature of
atypical parkinsonisms with tauopathies, such as progressive supranuclear palsy and …

In neuronal cells, tau is a microtubule-associated protein placed in axons and alpha
synuclein is enriched at presynaptic terminals. They display a propensity to form pathologic …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders,
characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In …

Many studies have been directed at understanding mechanisms of tau aggregation and
therapeutics, nearly all focusing on the brain. It is critical to understand the presence of tau in …

Over the last two decades there have been meaningful developments on biomarkers of
neurodegenerative diseases, extensively (but not solely) focusing on their proteinopathic …

Background: Previous studies reported skin phosphorylated α-synuclein (p-syn) deposits in
Parkinson's disease (PD) patients but not in patients with parkinsonism due to tauopathies …

There is increasing evidence suggesting that amyloidogenic proteins might form deposits in
non-neuronal tissues in neurodegenerative disorders such as Alzheimer's or Parkinson's …