In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

The Gram-negative bacterial lipopolysaccharide (LPS) is a major component of the outer
membrane that plays a key role in host–pathogen interactions with the innate immune …

Rationale: Eradication and suppression of Pseudomonas aeruginosa is a key priority in
national guidelines for bronchiectasis and is a major focus of drug development and clinical …

Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in
driving this process. However, there is increasing evidence that bacterial antibiotic …

Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to
coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of …

Bacterial virulence is highly dynamic and context-dependent. For this reason, it is
challenging to predict how molecular changes affect the growth of a pathogen in a host and …

Biofilms are communities of aggregated bacterial cells embedded in a self-produced
extracellular polymeric matrix. Biofilms are recalcitrant to antibiotic treatment and immune …

In patients with cystic fibrosis (CF), the lung is a remarkable ecological niche in which the
microbiome is subjected to important selective pressures. An inexorable colonization by …

Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

Otitis media is a common childhood infection of the middle ear and a major cause of
morbidity. This multifactorial disease manifests as a spectrum of clinical syndromes from …