AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular
energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role …

Liver cancer is among the leading global healthcare issues associated with high morbidity
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …

The AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that
regulates cellular and whole‐body energy balance. A recently reported crystal structure has …

The identification of a complex containing the tumor suppressor LKB1 as the critical
upstream kinase required for the activation of AMP-activated protein kinase (AMPK) by …

The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as
protein kinase B) phosphorylates Ser487 in the 'ST loop'(serine/threonine-rich loop) within …

Chronic infection with the hepatitis C virus (HCV) is a major risk factor for the development of
hepatocellular carcinoma (HCC) worldwide. The pathogenesis of HCC in HCV infection has …

The hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and
hepatocellular carcinoma worldwide. A significant portion of the morbidity and mortality …

Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …

The NS5A protein of hepatitis C virus is believed to be an integral part of the viral replicase.
Despite extensive investigation, the role of this protein remains elusive. Only limited …

The non-structural 5A (NS5A) protein of hepatitis C virus (HCV) has been the subject of
intensive research over the last decade. It is generally accepted that NS5A is a pleiotropic …