Partner and localizer of BRCA2 (PALB2) is vital for homologous recombination (HR) repair
in response to DNA double-strand breaks (DSBs). PALB2 functions as a tumor suppressor …

The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad
of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF …

Human MRG15 is a transcription factor that plays a vital role in embryonic development, cell
proliferation and cellular senescence. It comprises a putative chromo domain in the N …

The male-specific lethal (MSL) complex is required for dosage compensation in Drosophila
melanogaster, and analogous complexes exist in mammals. We report structures of binary …

Ash1 is a Trithorax group protein that possesses H3K36-specific histone methyltransferase
activity, which antagonizes Polycomb silencing. Here we report the identification of two Ash1 …

The evolutionarily conserved Trithorax group protein Ash1 is a SET domain histone
methyltransferase that mono-and dimethylates lysine 36 of histone H3 (H3K36). Ash1 forms …

Leishmaniases are a collection of neglected tropical diseases caused by kinetoplastid
parasites in the genus Leishmania. Current chemotherapies are severely limited, and the …

Leishmania are unicellular parasites that cause human and animal diseases. Like other
kinetoplastids, they possess large transcriptional start regions (TSRs) which are defined by …

Cullin (CUL) proteins have critical roles in development and cancer, however few studies on
CUL7 have been reported due to its characteristic molecular structure. CUL7 forms a …

MORF4-related gene on chromosome 15 (MRG15), a chromatin remodeller, is evolutionally
conserved and ubiquitously expressed in mammalian tissues and cells. MRG15 plays vital …