Molecular and cellular basis of genetically inherited skeletal muscle disorders

JJ Dowling, CC Weihl, MJ Spencer - Nature Reviews Molecular Cell …, 2021 - nature.com
Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin

Z Wang, M Grange, S Pospich, T Wagner, AL Kho… - Science, 2022 - science.org
In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the
underlying mechanism remains nebulous. In this work, we used cryo–electron tomography …

The mechanisms of thin filament assembly and length regulation in muscles

S Szikora, P Görög, J Mihály - International journal of molecular sciences, 2022 - mdpi.com
The actin containing tropomyosin and troponin decorated thin filaments form one of the
crucial components of the contractile apparatus in muscles. The thin filaments are organized …

Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

Y Qian, X Wang, J Song, W Chen, S Chen… - npj Regenerative …, 2021 - nature.com
As the application of graphene nanomaterials gets increasingly attractive in the field of
tissue engineering and regenerative medicine, the long-term evaluation is necessary and …

A nemaline myopathy–linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin

LE Schultz, M Colpan, GE Smith Jr… - Proceedings of the …, 2023 - National Acad Sciences
Actin is a highly expressed protein in eukaryotic cells and is essential for numerous cellular
processes. In particular, efficient striated muscle contraction is dependent upon the precise …

Transcriptome analysis reveals the molecular regulatory network of muscle development and meat quality in Sunit lamb supplemented with dietary probiotic

M Zhang, Y Guo, R Su, M Corazzin, R Hou, J Xie… - Meat Science, 2022 - Elsevier
Supplementing animal feed with probiotic additives can promote muscle production and
improve meat quality. The study aimed to explore the effects of dietary probiotics …

Postmortem Muscle Proteome Characteristics of Silver Carp (Hypophthalmichthys molitrix): Insights from Full-Length Transcriptome and Deep 4D Label-Free …

X Jiao, X Li, N Zhang, W Zhang, B Yan… - Journal of Agricultural …, 2024 - ACS Publications
The coverage of the protein database directly determines the results of shotgun proteomics.
In this study, PacBio single-molecule real-time sequencing technology was performed on …

Postnatal skeletal muscle myogenesis governed by signal transduction networks: MAPKs and PI3K–Akt control multiple steps

T Endo - Biochemical and Biophysical Research …, 2023 - Elsevier
Skeletal muscle myogenesis represents one of the most intensively and extensively
examined systems of cell differentiation, tissue formation, and regeneration. Muscle …

The role of leiomodin in actin dynamics: A new road or a secret gate

D Tolkatchev, CC Gregorio, AS Kostyukova - The FEBS journal, 2022 - Wiley Online Library
Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular,
animal model, and human data accumulate, the mechanisms of its action become clearer …

Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy

R Sono, TM Larrinaga, A Huang, F Makhlouf, X Kang… - Cells, 2023 - mdpi.com
As an essential component of the sarcomere, actin thin filament stems from the Z-disk extend
toward the middle of the sarcomere and overlaps with myosin thick filaments. Elongation of …