[HTML][HTML] MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

KKW To, CWS Tong, M Wu… - World journal of …, 2018 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small, single-stranded, noncoding RNAs that can post-
transcriptionally regulate the expression of various oncogenes and tumor suppressor genes …

Colon cancer therapy by focusing on colon cancer stem cells and their tumor microenvironment

Z Jahanafrooz, J Mosafer, M Akbari… - Journal of cellular …, 2020 - Wiley Online Library
Despite many advances and optimization in colon cancer treatment, tumor recurrence and
metastases make the development of new therapies necessary. Colon cancer stem cells …

LncRNA–FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 signaling

Z Bian, J Zhang, M Li, Y Feng, X Wang, J Zhang… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Long non-coding RNAs (lncRNAs) play key roles in human cancers. Here,
FEZF1-AS1, a highly overexpressed lncRNA in colorectal cancer, was identified by lncRNA …

[HTML][HTML] LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p

Z Bian, L Jin, J Zhang, Y Yin, C Quan, Y Hu, Y Feng… - Scientific reports, 2016 - nature.com
Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding
RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in …

The immune-microenvironment confers chemoresistance of colorectal cancer through macrophage-derived IL6

Y Yin, S Yao, Y Hu, Y Feng, M Li, Z Bian, J Zhang… - Clinical Cancer …, 2017 - AACR
Abstract Purpose: Tumor-associated macrophages (TAMs) are frequently associated with
poor prognosis in human cancers. However, the effects of TAMs in colorectal cancer are …

The role of microRNAs in colorectal cancer

AJ Schetter, H Okayama, CC Harris - The Cancer Journal, 2012 - journals.lww.com
During the last decade, it has become clear that aberrant microRNA expression has a
functional role in the initiation and progression of colorectal cancer (CRC). Specific …

MicroRNAs: Potential candidates for diagnosis and treatment of colorectal cancer

A Moridikia, H Mirzaei, A Sahebkar… - Journal of cellular …, 2018 - Wiley Online Library
Colorectal cancer (CRC) is known as the third common cancer worldwide and an important
public health problem in different populations. Several genetics and environmental risk …

[HTML][HTML] The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer

L Zhao, H Yu, S Yi, X Peng, P Su, Z Xiao, R Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract microRNAs (miRNAs) play critical roles in cancer development and progression.
This study investigated the effects of miR-138-5p in human colorectal cancer (CRC) …

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

RD Teasdale, BM Collins - Biochemical Journal, 2012 - portlandpress.com
The mammalian genome encodes 49 proteins that possess a PX (phox-homology) domain,
responsible for membrane attachment to organelles of the secretory and endocytic system …

miR-204-5p inhibits proliferation and invasion and enhances chemotherapeutic sensitivity of colorectal cancer cells by downregulating RAB22A

Y Yin, B Zhang, W Wang, B Fei, C Quan, J Zhang… - Clinical cancer …, 2014 - AACR
Abstract Purpose: miR-204-5p was found to be downregulated in colorectal cancer tissues
in our preliminary microarray analyses. However, the function of miR-204-5p in colorectal …