Cell signaling plays a key role in the development of all multicellular organisms. Numerous
studies have established the importance of Hedgehog signaling in a wide variety of …

Since its discovery five years ago the conserved family of fork head/HNF-3-related
transcription factors has gained increasing importance for the analysis of gene regulatory …

Expression of the Drosophila segment polarity genes is initiated by a pre-pattern of pair-rule
gene products and maintained by a network of regulatory interactions throughout several …

We report the cloning and primary structure of the Drosophila insulin receptor gene (inr),
functional expression of the predicted polypeptide, and the isolation of mutations in the inr …

Interactions between genes and gene products give rise to complex circuits that enable cells
to process information and respond to external signals. Theoretical studies often describe …

This paper proposes a new method to reverse engineer gene regulatory networks from
experimental data. The modeling framework used is time-discrete deterministic dynamical …

Hedgehog (Hh) signals regulate invertebrate and vertebrate development, yet the role of the
cascade in adipose development was undefined. To analyze a potential function, we turned …

Members of the Hedgehog (Hh) family of secreted proteins have been identified recently as
key signaling molecules that regulate a variety of inductive interactions central to the …

Embryonic development is an emergent process in which increasing complexity is
generated by sequential cellular interactions. Recently, it has become clear that such …

Given the complexity and interactive nature of biological systems, constructing informative
and coherent network models of these systems and subsequently developing efficient …