Metals to combat antimicrobial resistance

A Frei, AD Verderosa, AG Elliott, J Zuegg… - Nature Reviews …, 2023 - nature.com
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

SJ Tabrizi, MD Flower, CA Ross, EJ Wild - Nature Reviews Neurology, 2020 - nature.com
Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …

Huntington's disease: a clinical review

P McColgan, SJ Tabrizi - European journal of neurology, 2018 - Wiley Online Library
Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

Current and possible future therapeutic options for Huntington's disease

MW Ferguson, CJ Kennedy… - Journal of central …, 2022 - journals.sagepub.com
Huntington's disease (HD) is an autosomal neurodegenerative disease that is characterized
by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD …

Huntington disease

GP Bates, R Dorsey, JF Gusella, MR Hayden… - Nature reviews Disease …, 2015 - nature.com
Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Biomedical applications of copper ionophores

V Oliveri - Coordination Chemistry Reviews, 2020 - Elsevier
Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility
of applying copper ionophores to regenerate the metal homeostasis and treat copper …

Clinical practice with anti-dementia drugs: a revised (third) consensus statement from the British Association for Psychopharmacology

JT O'Brien, C Holmes, M Jones… - Journal of …, 2017 - journals.sagepub.com
The British Association for Psychopharmacology coordinated a meeting of experts to review
and revise its previous 2011 guidelines for clinical practice with anti-dementia drugs. As …

Metals and Parkinson's disease: mechanisms and biochemical processes

G Bjorklund, V Stejskal, MA Urbina… - Current Medicinal …, 2018 - ingentaconnect.com
Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease
(PD), while the remaining cases are of unknown etiology. It is believed that environmental …

Therapeutic approaches to Huntington disease: from the bench to the clinic

NS Caron, ER Dorsey, MR Hayden - Nature Reviews Drug Discovery, 2018 - nature.com
The 25 years since the identification of the gene responsible for Huntington disease (HD)
have stood witness to profound discoveries about the nature of the disease and its …

Polyphenols as potential metal chelation compounds against Alzheimer's disease

J Lakey-Beitia, AM Burillo, G La Penna… - Journal of …, 2021 - content.iospress.com
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …