The exponential increase in sequencing data calls for conceptual and computational
advances to extract useful biological insights. One such advance, minimizers, allows for …

A pangenome is a collection of the common and unique genomes that are present in a given
species. It combines the genetic information of all the genomes sampled, resulting in a large …

Pangenomes are replacing single reference genomes as the definitive representation of
DNA sequence within a species or clade. Pangenome analysis predominantly leverages …

Co-linear chaining is a widely used technique in sequence alignment tools that follow seed-
filter-extend methodology. It is a mathematically rigorous approach to combine short exact …

Elastic Degenerate (ED) strings and Elastic Founder (EF) graphs are two versions of acyclic
components of pangenomes. Both ED strings and EF graphs (which we collectively name …

Presenting the fundamental algorithms and data structures that power bioinformatics
workflows, this book covers a range of topics from the foundations of sequence analysis …

A pangenome graph can serve as a better reference for genomic studies because it allows a
compact representation of multiple genomes within a species. Aligning sequences to a …

Constructing and personalizing population pangenome graphs | Nature Methods Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Abstract Motivation The Positional Burrows–Wheeler Transform (PBWT) is a data structure
that indexes haplotype sequences in a manner that enables finding maximal haplotype …

Pangenomics is a relatively new scientific field which investigates the union of all the
genomes of a clade. The word pan means everything in ancient Greek; the term …