This review discusses the control exerted by natural CD4+ CD25+ regulatory T cells (natural
Treg cells) during infectious processes. Natural Treg cells may limit the magnitude of effector …

Malaria causes an acute systemic human disease that bears many similarities, both
clinically and mechanistically, to those caused by bacteria, rickettsia, and viruses. Over the …

Cerebral malaria claims more than 1 million lives per year. We report that heme oxygenase-
1 (HO-1, encoded by Hmox1) prevents the development of experimental cerebral malaria …

Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …

The induction of cellular immunity, in conjunction with antibodies, may be essential for
vaccines to protect against blood-stage infection with the human malaria parasite …

There is considerable debate as to the nature of the primary parasite-derived moieties that
activate innate pro-inflammatory responses during malaria infection. Microparticles (MPs) …

It is well established that IFN-γ is required for the development of experimental cerebral
malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice. However, the …

Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of
cerebral malaria is poorly defined and progress in understanding the condition is severely …

The innate immune system is an evolutionally conserved host defense mechanism against
pathogens. Innate immune responses are initiated by pattern recognition receptors (PRRs) …

Chronic helminth infections induce strong type 2 and regulatory immune responses and are
known to influence immune activity to other antigens such as allergens and vaccines. Since …