Vaccine adjuvants: mechanisms and platforms
T Zhao, Y Cai, Y Jiang, X He, Y Wei, Y Yu… - Signal transduction and …, 2023 - nature.com
Adjuvants are indispensable components of vaccines. Despite being widely used in
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …
vaccines, their action mechanisms are not yet clear. With a greater understanding of the …
Emerging concepts in the science of vaccine adjuvants
B Pulendran, P S. Arunachalam… - Nature Reviews Drug …, 2021 - nature.com
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …
the immune response. Following its introduction in the 1920s, alum remained the only …
Immunological considerations for COVID-19 vaccine strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
Metallodrugs are unique: Opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Toward nanotechnology-enabled approaches against the COVID-19 pandemic
The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment
as well as mitigation of the spread of infection, all through large-scale approaches such as …
as well as mitigation of the spread of infection, all through large-scale approaches such as …
Polymersome-based protein drug delivery–quo vadis?
MG Gouveia, JP Wesseler, J Ramaekers… - Chemical Society …, 2023 - pubs.rsc.org
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …
approaches and represent one of the fastest growing families of drugs. While many of these …
Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
C Pifferi, R Fuentes, A Fernández-Tejada - Nature Reviews Chemistry, 2021 - nature.com
Modern subunit vaccines based on homogeneous antigens offer more precise targeting and
improved safety compared with traditional whole-pathogen vaccines. However, they are also …
improved safety compared with traditional whole-pathogen vaccines. However, they are also …
New-age vaccine adjuvants, their development, and future perspective
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …
protects us from infectious agents. Despite the great success in the field of vaccinology …
A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
While the rapid development of COVID-19 vaccines has been a scientific triumph, the need
remains for a globally available vaccine that provides longer-lasting immunity against …
remains for a globally available vaccine that provides longer-lasting immunity against …
Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity
In conjugate, inactivated, recombinant, and toxoid vaccines, adjuvants are extensively and
essentially used for enhanced and long-lasting protective immune responses. Depending …
essentially used for enhanced and long-lasting protective immune responses. Depending …