A call for systematic research on solute carriers
A Cesar-Razquin, B Snijder, T Frappier-Brinton… - Cell, 2015 - cell.com
Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …
PP2A as a master regulator of the cell cycle
N Wlodarchak, Y Xing - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
[HTML][HTML] Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Thousands of interactions assemble proteins into modules that impart spatial and functional
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
Gene essentiality and synthetic lethality in haploid human cells
Although the genes essential for life have been identified in less complex model organisms,
their elucidation in human cells has been hindered by technical barriers. We used extensive …
their elucidation in human cells has been hindered by technical barriers. We used extensive …
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target
of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels …
of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels …
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery
X Liu, S Huuskonen, T Laitinen, T Redchuk… - Molecular Systems …, 2021 - embopress.org
Abstract Treatment options for COVID‐19, caused by SARS‐CoV‐2, remain limited.
Understanding viral pathogenesis at the molecular level is critical to develop effective …
Understanding viral pathogenesis at the molecular level is critical to develop effective …
Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities
Robust characterization of the protein corona—the layer of proteins that spontaneously
forms on the surface of nanoparticles immersed in biological fluids—is vital for prediction of …
forms on the surface of nanoparticles immersed in biological fluids—is vital for prediction of …
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9
Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of
immune responses,–. Here we show that a previously uncharacterized protein encoded by …
immune responses,–. Here we show that a previously uncharacterized protein encoded by …
An AP-MS-and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations
Protein-protein interactions govern almost all cellular functions. These complex networks of
stable and transient associations can be mapped by affinity purification mass spectrometry …
stable and transient associations can be mapped by affinity purification mass spectrometry …
Combined proximity labeling and affinity purification− mass spectrometry workflow for mapping and visualizing protein interaction networks
X Liu, K Salokas, RG Weldatsadik, L Gawriyski… - Nature protocols, 2020 - nature.com
Affinity purification coupled with mass spectrometry (AP–MS) and proximity-dependent
biotinylation identification (BioID) methods have made substantial contributions to …
biotinylation identification (BioID) methods have made substantial contributions to …