All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …

Palmitoylethanolamide (PEA, N-hexadecanoylethanolamide) is an endogenous compound
belonging to the family of N-acylethanolamines. PEA has anti-inflammatory and analgesic …

Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and
to be devoid of unwanted effects. Here, we have examined critically this contention, and …

Growing evidence supports the pivotal role played by oxidative stress in tissue injury
development, thus resulting in several pathologies including cardiovascular, renal …

Chronic inflammation and oxidative stress, features that are closely associated with nuclear
factor (NF-κB) activation, play a key role in the development and progression of chronic …

Objective—Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized
from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its …

Palmitoylethanolamide (PEA) is a food component known since 1957. PEA is synthesized
and metabolized in animal cells via a number of enzymes and exerts a multitude of …

Background Experimental studies provide evidence for antidepressant effects of
Palmitoylethanolamide (PEA) in animal models of depression. We aimed to evaluate the …

Acute and chronic inflammation responses are important risk factors for vascular remodeling
processes such as in atherosclerosis, arteriosclerosis and restenosis. Inflammation and …

Current epidemiological data estimate that one in five people suffers from chronic pain with
considerable impairment of health-related quality of life. The pharmacological treatment is …