Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a
peroxisome proliferator-activated receptor-α (PPAR-α) agonist, is a classic drug for treating …

Ischemia/reperfusion (IR) injury contributes to disability and mortality worldwide. Due to the
complicated mechanisms and lack of proper therapeutic targets, few interventions are …

Rationale: Previous studies have suggested that myocardial inflammation plays a critical
role after ischemic myocardial infarction (MI); however, the underlying mechanisms still need …

BACKGROUND: SR-B1 (scavenger receptor class B type 1)/LDLR (low-density lipoprotein
receptor) double knockout mice fed a high-fat, high-cholesterol diet containing cholate …

Anthracycline antineoplastic agents such as doxorubicin are widely used and highly
effective component of adjuvant chemotherapy for breast cancer and curative regimens for …

Coronary artery disease, including myocardial infarction (MI), remains a leading cause of
global mortality. Rapid reperfusion therapy is key to the improvement of patient outcome but …

Myocardial infarction refers to myocardial necrosis caused by acute or persistent coronary
ischemia and hypoxia. It is considered to be one of the significant crises threatening human …

Background Protease‐activated receptor 4 (PAR4) is expressed by a wide variety of cells,
including megakaryocytes/platelets, immune cells, cardiomyocytes, and lung epithelial cells …

After myocardial infarction (MI), cardiac cells work together to regulate wound healing of the
infarct. The pathological response to MI yields cardiac remodelling comprising inflammatory …

Myocardial fibrosis is a feature found in most cardiac diseases and a key element
contributing to heart failure and its progression. It has therefore become a subject of …