The tandem stenosis mouse model: towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture
J Noonan, A Bobik, K Peter - British journal of pharmacology, 2022 - Wiley Online Library
The rupture of unstable atherosclerotic plaques is the major cause of cardiovascular
mortality and morbidity. Despite significant limitations in our understanding and ability to …
mortality and morbidity. Despite significant limitations in our understanding and ability to …
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein
C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in
response to inflammatory reactions. We recently identified a novel mechanism that leads to …
response to inflammatory reactions. We recently identified a novel mechanism that leads to …
Plasma levels of trimethylamine-N-oxide can be increased with 'healthy'and 'unhealthy'diets and do not correlate with the extent of atherosclerosis but with plaque …
Aims The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has attracted
major interest and controversy both as a diagnostic biomarker and therapeutic target in …
major interest and controversy both as a diagnostic biomarker and therapeutic target in …
[HTML][HTML] Platelet lipidome: Dismantling the “Trojan horse” in the bloodstream
M Chatterjee - Journal of Thrombosis and Haemostasis, 2020 - Elsevier
The platelet‐lipid chapter in the story of atherothrombosis is an old one, recapitulated and
revised in many contexts. For decades several stimulating facets have been added to it, both …
revised in many contexts. For decades several stimulating facets have been added to it, both …
Platelet ACKR3/CXCR7 favors antiplatelet lipids over an atherothrombotic lipidome and regulates thromboinflammation
M Cebo, K Dittrich, X Fu, MC Manke… - Blood, The Journal …, 2022 - ashpublications.org
Platelet ACKR3/CXCR7 surface expression is enhanced and influences prognosis in
coronary artery disease (CAD) patients, who exhibit a distinct atherothrombotic platelet …
coronary artery disease (CAD) patients, who exhibit a distinct atherothrombotic platelet …
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation–implications in atherosclerosis
Objective: The mechanisms involved in NOX5 activation in atherosclerotic processes are not
completely understood. The present study tested the hypothesis that …
completely understood. The present study tested the hypothesis that …
P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells
PM Siegel, L Sander, A Fricke, J Stamm, X Wang… - Scientific reports, 2021 - nature.com
P2Y12 blockade improves patient outcomes after myocardial infarction. As well as
antithrombotic effects, anti-inflammatory effects may contribute to this beneficial clinical …
antithrombotic effects, anti-inflammatory effects may contribute to this beneficial clinical …
Mass spectrometry imaging as a tool to investigate region specific lipid alterations in symptomatic human carotid atherosclerotic plaques
Atherosclerosis is characterized by fatty plaques in large and medium sized arteries. Their
rupture can causes thrombi, occlusions of downstream vessels and adverse clinical events …
rupture can causes thrombi, occlusions of downstream vessels and adverse clinical events …
Platelet-derived microvesicles activate human platelets via intracellular calcium mediated reactive oxygen species release
Platelet-derived microvesicles (PMVs) are the most abundant microvesicles in circulation,
originating from blood platelets via membrane blebbing. PMVs act as biological cargo …
originating from blood platelets via membrane blebbing. PMVs act as biological cargo …
Status of biomarkers for the identification of stable or vulnerable plaques in atherosclerosis
V Lubrano, S Balzan - Clinical Science, 2021 - portlandpress.com
Atherosclerosis is a systemic inflammation of the arteries characterized by atherosclerotic
plaque due to the accumulation of lipids, inflammatory cells, apoptotic cells, calcium and …
plaque due to the accumulation of lipids, inflammatory cells, apoptotic cells, calcium and …