Cells acquire their ultimate identities by activating combinations of transcription factors that
initiate and sustain expression of the appropriate cell type-specific genes. T cell …

Coordinated function of the innate and adaptive arms of the immune system in vertebrates is
essential to promote protective immunity and to avoid immunopathology. The Notch …

Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …

The vertebrate thymus provides an inductive environment for T-cell development. Within the
mouse thymus, Notch signals are indispensable for imposing the T-cell fate on multipotential …

The production of cytokines such as interferon-γ and interleukin 17 by αβ and γδ T cells
influences the outcome of immune responses. Here we show that most γδ T lymphocytes …

Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

The Notch signaling pathway regulates many aspects of embryonic development, as well as
differentiation processes and tissue homeostasis in multiple adult organ systems …

T cell receptor (TCR) β-selection (herein referred to as β-selection) is a pivotal checkpoint in
mammalian T cell development when immature CD4–CD8–T-cells (thymocytes) express pre …

The identities of the regulators that mediate commitment of hematopoietic precursors to the T
lymphocyte lineage have been unknown. The last stage of T lineage commitment in vivo …