The field of lipidomics, as coined in 2003, has made profound advances and been rapidly
expanded. The mass spectrometry-based strategies of this analytical methodology-oriented …

Ceramides are sphingolipids and integral components of the eukaryotic cell membrane.
Apart from providing structural integrity, ceramides have also been shown to act as second …

Objectives: To investigate whether serum neurofilament light (NfL) concentration is
increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and …

Introduction Metabolite, lipid, and lipoprotein lipid profiling can provide novel insights into
mechanisms underlying incident dementia and Alzheimer's disease. Methods We studied …

Alzheimer's Disease (AD) currently affects more than 5 million Americans, with numbers
expected to grow dramatically as the population ages. The pathophysiological changes in …

Alzheimer's disease (AD), the most common chronic and progressive neurodegenerative
disorder, is characterized by extracellular deposits of amyloid β‐peptides (Aβ) and …

Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To
gain a more comprehensive understanding of what causes AD and its subsequent …

Abstract Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of
easily accessible biomarkers that can detect disease presence and predict disease risk …

The brain is highly enriched in lipids, and an intensive study of these lipids may be
informative, not only of normal brain function but also of changes with age and in disease. In …

Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) deposition, which
activates microglia, induces neuroinflammation and drives neurodegeneration. Recent …