Lysosomes as a therapeutic target
SR Bonam, F Wang, S Muller - Nature reviews Drug discovery, 2019 - nature.com
Lysosomes are membrane-bound organelles with roles in processes involved in degrading
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …
and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes …
The roles of autophagy in cancer
CW Yun, SH Lee - International journal of molecular sciences, 2018 - mdpi.com
Autophagy is an intracellular degradative process that occurs under several stressful
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …
conditions, including organelle damage, the presence of abnormal proteins, and nutrient …
Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity
Metabolic coordination between neurons and astrocytes is critical for the health of the brain.
However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural …
However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
[HTML][HTML] Mitochondria–lysosome crosstalk: from physiology to neurodegeneration
Cellular function requires coordination between different organelles and metabolic cues.
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …
Mitochondria and lysosomes are essential for cellular metabolism as major contributors of …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story
The anti-malarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been
suggested as promising agents against the new coronavirus SARS-CoV-2 that induces …
suggested as promising agents against the new coronavirus SARS-CoV-2 that induces …
Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion
YH Kim, MS Kwak, B Lee, JM Shin, S Aum, IH Park… - Autophagy, 2021 - Taylor & Francis
Nuclear protein HMGB1 is secreted in response to various stimuli and functions as a danger-
associated molecular pattern. Extracellular HMGB1 induces inflammation, cytokine …
associated molecular pattern. Extracellular HMGB1 induces inflammation, cytokine …
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …