Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation

I Lingvay, P Sumithran, RV Cohen, CW le Roux - The Lancet, 2022 - thelancet.com
Obesity is now recognised as a disease that is associated with serious morbidity and
increased mortality. One of its main metabolic complications is type 2 diabetes, as the two …

Metabolically healthy obesity

M Blüher - Endocrine reviews, 2020 - academic.oup.com
Obesity contributes to reduced life expectancy, impaired quality of life, and disabilities,
mainly in those individuals who develop cardiovascular diseases, type 2 diabetes …

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

European Association for the Study of the Liver (EASL)… - Obesity Facts, 2024 - karger.com
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-
alcoholic fatty liver disease (NAFLD), is defined as steatotic liver disease (SLD) in the …

Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures–2019 update: cosponsored …

JI Mechanick, C Apovian, S Brethauer… - Surgery for Obesity and …, 2020 - Elsevier
Objective The development of these updated clinical practice guidelines (CPG) was
commissioned by the American Association of Clinical Endocrinologists, The Obesity …

Diabetes Mellitus: insights from epidemiology, biochemistry, risk factors, diagnosis, complications and comprehensive management

S Alam, MK Hasan, S Neaz, N Hussain, MF Hossain… - Diabetology, 2021 - mdpi.com
Diabetes mellitus has become a serious and chronic metabolic disorder that results from a
complex interaction of genetic and environmental factors, principally characterized by …

Metabolic surgery in the treatment algorithm for type 2 diabetes: a joint statement by international diabetes organizations

F Rubino, DM Nathan, RH Eckel, PR Schauer… - Diabetes …, 2016 - Am Diabetes Assoc
BACKGROUND Despite growing evidence that bariatric/metabolic surgery powerfully
improves type 2 diabetes (T2D), existing diabetes treatment algorithms do not include …

Differentiation of diabetes by pathophysiology, natural history, and prognosis

JS Skyler, GL Bakris, E Bonifacio, T Darsow… - Diabetes, 2017 - Am Diabetes Assoc
The American Diabetes Association, JDRF, the European Association for the Study of
Diabetes, and the American Association of Clinical Endocrinologists convened a research …

Prevention of cardiorenal complications in people with type 2 diabetes and obesity

DJ Drucker - Cell Metabolism, 2024 - cell.com
Traditional approaches to prevention of the complications of type 2 diabetes (T2D) and
obesity have focused on reduction of blood glucose and body weight. The development of …

Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery

R Taylor, A Al-Mrabeh, S Zhyzhneuskaya, C Peters… - Cell metabolism, 2018 - cell.com
Summary The Diabetes Remission Clinical Trial reported return and persistence of non-
diabetic blood glucose control in 46% of people with type 2 diabetes of up to 6 years …

The role of bariatric surgery to treat diabetes: current challenges and perspectives

C Koliaki, S Liatis, CW Le Roux, A Kokkinos - BMC endocrine disorders, 2017 - Springer
Bariatric surgery is emerging as a powerful weapon against severe obesity and type 2
diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract …