Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to
external cues to regulate the many uses of DNA. A principle component of chromatin that …

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has
become clear that the DNA and histone lysine methylation systems are highly interrelated …

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to
conveying the epigenetic program, it is still unclear how a defined chromatin domain is …

Mammals use DNA methylation for the heritable silencing of retrotransposons and imprinted
genes and for the inactivation of the X chromosome in females. The establishment of …

Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive posttranslational
modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the …

Transposons populate the landscape of all eukaryotic genomes. Often considered purely
genomic parasites, transposons can also benefit their hosts, playing roles in gene regulation …

Histone lysine methylation is a central modification to mark functionally distinct chromatin
regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric …

The SET-domain protein superfamily: protein lysine methyltransferases | Genome Biology Skip
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Methylation of position-specific lysine residues in histone N termini is a central modification
for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist …