Microbial fibrinolytic enzymes as anti-thrombotics: production, characterisation and prodigious biopharmaceutical applications

C Sharma, A Osmolovskiy, R Singh - Pharmaceutics, 2021 - mdpi.com
Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

The evolution of recombinant thrombolytics: Current status and future directions

Adivitiya, YP Khasa - Bioengineered, 2017 - Taylor & Francis
Cardiovascular disorders are on the rise worldwide due to alcohol abuse, obesity,
hypertension, raised blood lipids, diabetes and age-related risks. The use of classical …

Purification and characterization of a novel, highly potent fibrinolytic enzyme from Bacillus subtilis DC27 screened from Douchi, a traditional Chinese fermented …

Y Hu, D Yu, Z Wang, J Hou, R Tyagi, Y Liang, Y Hu - Scientific reports, 2019 - nature.com
The highly fibrinolytic enzyme-producing bacterium was identified as Bacillus subtilis DC27
and isolated from Douchi, a traditional fermented soybean food. The DFE27 enzyme was …

An intelligentized strategy for endogenous small molecules characterization and quality evaluation of earthworm from two geographic origins by ultra-high …

J Zhang, W Yang, S Li, S Yao, P Qi, Z Yang… - Analytical and …, 2016 - Springer
Animal-derived medicines have been a vital component for traditional Chinese medicine.
However, their quality control remains challenging due to the large polarity of the contained …

Preclinical evaluation and clinical translation of magnetite-based nanomedicines

JV Nuzhina, AA Shtil, AY Prilepskii… - Journal of Drug Delivery …, 2019 - Elsevier
Over the last decade, magnetic iron oxide nanoparticles have attracted considerable interest
in the field of nanomedicine due to their unique magnetic properties, biocompatibility, and …

Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm-related infections

S Hogan, M Zapotoczna, NT Stevens… - Journal of Hospital …, 2017 - Elsevier
Staphylococcus aureus is a leading cause of healthcare-associated infections. The ability of
S. aureus to attach and subsequently accumulate on the surfaces of implanted medical …

Thrombolytic Potential of Novel Thiol-Dependent Fibrinolytic Protease from Bacillus cereus RSA1

C Sharma, GEM Salem, N Sharma, P Gautam, R Singh - Biomolecules, 2019 - mdpi.com
The present study demonstrates the production and thrombolytic potential of a novel
thermostable thiol-dependent fibrinolytic protease by Bacillus cereus RSA1. Statistical …

Production, purification, and functional properties of microbial fibrinolytic enzymes produced by microorganism obtained from soy-based fermented foods …

M Yao, Y Yang, J Fan, C Ma, X Liu… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract According to the World Health Organization, cardiovascular disease (CVD) has
become a major cause of chronic illness around the globe. It has been reported that soy …

Fibrinolytic enzymes for thrombolytic therapy

SS Kumar, A Sabu - Therapeutic enzymes: function and clinical …, 2019 - Springer
Cardiovascular diseases are a group of disorders consisting importantly of coronary heart
disease, peripheral arterial disease, cerebrovascular disease, rheumatic heart disease …

Aspergillus ochraceus: Metabolites, Bioactivities, Biosynthesis, and Biotechnological Potential

RH Hareeri, MM Aldurdunji, HM Abdallah, AA Alqarni… - Molecules, 2022 - mdpi.com
Fungus continues to attract great attention as a promising pool of biometabolites. Aspergillus
ochraceus Wilh (Aspergillaceae) has established its capacity to biosynthesize a myriad of …